Unmet Need in Osteoarthritis

Osteoarthritis (OA) is a growing epidemic in the United States:

  • OA is the most common joint disease.
  • ~27 million Americans are affected, with numbers expected to grow as a result of aging, obesity and sports injuries.
  • The CDC estimates that 78 million Americans are projected to have a diagnosis of OA by 2040 compared to 53 million in 2010-2012.
  • Average age of physician-diagnosed knee OA has fallen by 16 years, from 72 in the 1990s to 56 in the 2010s.
  • Approximately 35% of U.S. adults are obese, which increases the risk of developing OA.
  • Knee injury is common, particularly amongst young athletes, and increases the risk of developing OA by more than fivefold.
  • 1 in 2 Americans is expected to develop symptomatic knee OA, the most common form of OA, during their lifetime.
  • OA accounts for over $185 billion of annual healthcare expenditures, which does not include loss of productivity costs.
  • CDC shows an increasing number of OA diagnoses, which will lead to additional healthcare resource utilization.
  • As reported in an Osteoarthritis Research Society International (OARSI) white paper (Nov 2016), “subjects in the US cohort with symptomatic radiographic knee OA were 23% more likely to die prematurely than people free from OA, independent of age, sex and race.”