Executive Committee

Michael Clayman, M.D. is a co-founder of Flexion Therapeutics and has served as our President, Chief Executive Officer and as one of our directors since our inception in 2007. Dr. Clayman also serves as the Chairman of the board of directors of both Anokion SA and Ribometrix Inc., both private biopharmaceutical companies. Previously, Dr. Clayman had a lengthy career at Eli Lilly and Company, where he was most recently Vice President, Lilly Research Laboratories, and General Manager of Chorus, Lilly’s early-phase development accelerator. During his career at Lilly, Dr. Clayman also led its Global Regulatory Affairs division, the Cardiovascular Discovery Research and Clinical Investigation, Research and Development at Advanced Cardiovascular Systems, a medical device subsidiary of Lilly, the Internal Medicine Division, the Lilly Clinic, Lilly’s dedicated Phase 1 unit, and served as Chair of Lilly’s Bioethics Committee. Prior to his tenure at Lilly, Dr. Clayman was an Assistant Professor in the School of Medicine at the University of Pennsylvania, where his research centered on the immunopathogenesis of renal disease. Dr. Clayman is the recipient of the Physician Scientist Award from the National Institutes of Health.  Dr. Clayman earned a B.A., cum laude, from Yale University and an M.D. from the University of California, San Diego School of Medicine. Following an internship and residency in Internal Medicine at the University of California, San Francisco Moffitt Hospitals, Dr. Clayman completed clinical and research fellowships in Nephrology at the University of Pennsylvania.

Dr. Andrews joins Flexion Therapeutics with more than 20 years of biopharmaceutical experience in clinical development, medical affairs, and medical/commercial strategy, including seven product launches.  Dr. Andrews most recently served as CMO at Akcea Therapeutics, a global biopharmaceutical company focused on the development and commercialization of RNA-targeting antisense oligonucleotide therapies for rare diseases. Prior to Akcea, Dr. Andrews served as CMO for Acer Therapeutics, where he managed and led clinical development programs for rare diseases in multiple therapeutic areas. He previously provided strategic consulting services on clinical development plan strategy and clinical trial design, medical affairs strategic plan development, go-to-market strategy and planning, buy-side asset analysis and corporate strategy as the Founder and Principal of Aletheia Lifesciences. In addition, Dr. Andrews held senior leadership positions and roles of increasing responsibility at Aegerion Pharmaceuticals, Santhera Pharmaceuticals, Sepracor, and ClinQuest.

Dr. Andrews practiced Internal Medicine full-time for seven years before joining industry and continued practicing after joining industry through 2012.  During this time, he served as Clinical Faculty in Internal Medicine at Harvard Medical School and Attending Physician in Internal Medicine at Brigham and Women’s Hospital in Boston. He earned his B.A. in Biology from Harvard University and his M.D. from Yale University School of Medicine.

Mr. Driscoll has more than 30 years of experience in financial management of life sciences companies. He previously served as Flexion’s Chief Financial Officer from 2013 to 2017, during his tenure he spearheaded an initial public offering in 2014 and was at the financial helm through the launch of ZILRETTA. Prior to joining Flexion, Mr. Driscoll served as Chief Financial Officer at Novavax, Inc.  from 2009 to 2013. From 2008 to 2009, he served as Chief Executive Officer of Genelabs Technologies, Inc., a publicly traded biopharmaceutical and diagnostics company later acquired by GlaxoSmithKline. Prior to serving as Chief Executive Officer of Genelabs he was the Chief Financial Officer from 2007 to 2008. From 2000 to 2006, Mr. Driscoll served as Chief Executive Officer at OXiGENE, Inc., where he also served as Chairman of the Board and Audit Committee Chair. He was also a member of the Audit Committee for Cynapsus Therapeutics, Inc., which was sold to Sunovion Pharmaceuticals in 2016. Mr. Driscoll earned a B.S. in accounting and finance from Bentley University. He is a member of the board of directors of Cue Biopharma, Cellectar Biosciences, Inc. and MEI Pharma, Inc.

Ms. Layman joins Flexion with more than 25 years of commercial experience within the life science industry. Over the course of her career Ms. Layman has held positions of increasing responsibility within the sales, marketing, commercial and market access functions. Most recently, Ms. Layman served as Vice President, Global Sales and Marketing at Lantheus Medical Imaging where she was a member of the executive leadership team. During her nearly 10-year tenure, Ms. Layman was responsible for global sales, marketing, communications, health policy, pricing and reimbursement, commercial development and international operations. Prior to Lantheus, she served as Executive Marketing Director at Forest Labs (now Allergan), where she led the cardiovascular franchise through the successful launch of its lead product, Bystolic. Previously Ms. Layman held senior marketing positions at Altus Pharmaceuticals (founded as subsidiary of Vertex) and Sepracor (now Sunovion), where she launched Xopenex MDI and Lunesta, building and integrating the market access function across the business. She began her career with TAP Pharmaceuticals (now Takeda Oncology) where her positions ranged from sales representative to National Marketing Director, Gastroenterology and Oncology.

Ms. Layman holds a B.A. from Ithaca College and an executive M.B.A. from the Kellogg School of Management at Northwestern University.

Mark Levine has more than 20 years of experience counseling companies on general corporate matters, including: strategic corporate development; complex commercial transactions; mergers, acquisitions and divestitures; licensing agreements and corporate partnerships; financings; securities law; corporate governance; and regulatory compliance. Prior to joining Flexion, Mr. Levine served as Senior Vice President, General Counsel and Corporate Secretary and a member of the executive management team of Minerva Neurosciences, Inc., a publicly traded biotechnology company. Mr. Levine has also served in senior legal positions at athenahealth, Inc., a network-based health internet technology company; Clinical Data, Inc., a biopharmaceutical company acquired by Forest Laboratories, Inc.; Wheelabrator Technologies Inc., a renewable energy company; and Xpedior Incorporated, an internet consulting company.

Mr. Levine holds a B.A. from Binghamton University, SUNY, and a J.D. from Washington University School of Law in St. Louis.

Dr. Muzikant joins Flexion with 18 years of hands-on leadership experience in biotechnology and specialty pharmaceuticals companies, and consulting firms. Most recently, he was Vice President, Business Development at Synta Pharmaceuticals, where he led the strategic transaction process culminating in a merger with Madrigal Pharmaceuticals, and subsequently negotiated out-licensing agreements for Synta’s oncology programs. Prior to Synta, Dr. Muzikant held business development leadership positions at AMAG Pharmaceuticals, Inotek Pharmaceuticals, EPIX Pharmaceuticals, and Predix Pharmaceuticals, and also performed transaction/strategic advisory work for biotechnology and pharmaceutical clients with Locust Walk Partners. Prior to moving into business development, Dr. Muzikant led an anti-arrhythmia drug discovery program at Predix targeting ion channels. He received his Ph.D. in biomedical engineering from Duke University, and a B.S. in bioengineering from the University of California, San Diego.

Ms. Wentworth brings more than 20 years of experience in both domestic and international Regulatory Affairs that spans early and late development across multiple therapeutic areas. Prior to joining Flexion, Ms. Wentworth served as Vice President, Clinical, Regulatory and Quality at Agenus, Inc., where she was responsible for leading all global regulatory and clinical development efforts for nearly 10 years. Previously, Ms. Wentworth led the Regulatory and Quality function for Genelabs Technologies, Inc., where she was responsible for advancing their lead program through Phase 3 development and into the registration phase with FDA and EMA. Ms. Wentworth also held positions of increasing responsibility within Regulatory Affairs at Genzyme. Ms. Wentworth holds a B.S. in pre-veterinary medicine from the University of New Hampshire.

Ms. Willwerth has more than 25 years of experience in pharmaceutical development. Most recently, Ms. Willwerth served as Flexion’s Senior Vice President of Program Management and Strategy, and in her expanded role she continues to lead the planning and execution of our strategic vision and business priorities and have accountability for Flexion’s portfolio development efforts and Human Resources activities. Ms. Willwerth joined Flexion Therapeutics from Viacell, where she was a member of the company’s Executive Management team and served as Vice President, Product Development, with management responsibility for the company’s interdisciplinary cellular therapy and fertility preservation development programs. She previously served as Senior Director, Product Development at The Medicines Company, where she focused on cardiovascular therapy clinical and product development. Prior to that, she held a number of ascendant clinical operations positions at Astra Pharmaceuticals and Biopure Corporation. Ms. Willwerth holds a B.S. in Biology, with high distinction, from Worcester Polytechnic Institute.